名古屋大学 大学院情報学研究科
 複雑系科学専攻 生命情報論講座
 塚本研究室

研究実績

  

  原著論文 (2010年以降)
1. Brønsted Acid-Catalyzed 1,4-Addition of 1,3,5-Trimethoxybenzene to Maleimides and
  Acrylates
  S. Hor, K.-i. Oyama, N. Koga, and M. Tsukamoto, Tetrahedron Lett. 74, 153100 (2021).
   
2. Experimental Study of Application of Molecules with a Cyclic Head Group Containing
  a Free Radical as Organic Friction Modifiers
  X. Zhang, M. Tsukamoto, H. Zhang, Y. Mitsuya, S. Itoh, and K. Fukuzawa,
  J. Adv. Mech. Des. Syst., 14, JAMDSM0044 (2020).
   
3. A Solid-Supported Acidic Oxazolium Perchlorate as an Easy-Handling Catalyst for
  the Synthesis of Modified Pyrimidine Nucleosides via Vorbrüggen-type N-Glycosylation.
  N. Basu, K.-i. Oyama, and M. Tsukamoto, Tetrahedron Lett., 58, 1921–1924 (2017).
   
4. Synthesis of Ribonucleoside 3',5'-Cyclic Monophosphorodithioates.
  A. Fukuhara and M. Tsukamoto, Tetrahedron, 71, 3878–3884 (2015).
   
5. Practical Synthesis of Adenosine 3',5'-Cyclic Monophosphorodithioate.
  A. Fukuhara, H. Morita, K.-i. Oyama, and M. Tsukamoto, Tetrahedron Lett., 55,
  5261–5263 (2014).
   
6. Synthesis of Modified Pyrimidine Nucleosides via Vorbrüggen-type N-Glycosylation
  Catalyzed by 2-Methyl-5-phenylbenzoxazolium Perchlorate.
  H. Shirouzu, H. Morita, and M. Tsukamoto, Tetrahedron, 70, 3635–3639 (2014).
   
7. Cyclic Bis(3'-5')diadenylic Acid (c-di-AMP) Analogs Promote the Activities of
  Photosynthesis and Respiration of Chlamydomonas reinhardtii.
  T. Tezuka, H. Shirouzu, K. Ishida, N. Suzuki, T. Matsuo, K.-i. Oyama, S. Aoki, and
  M. Tsukamoto, Am. J. Plant Sciences, 5, 24–28 (2014).
   
8. Synthesis of 2'-Modified Cyclic Bis(3'–5')diadenylic Acids (c-di-AMPs) and
  Their Promotion of Cell Division in a Freshwater Green Alga.
  T. Tezuka, N. Suzuki, K. Ishida, K.-i. Oyama, S. Aoki, and M. Tsukamoto, Chem. Lett.,
  41, 1723–1725 (2012).
   
9. Controlling Glycosyl Bond Conformation of Guanine Nucleosides: Stabilization of
  the anti Conformer in 5'-O-Ethylguanosine.
  H. Asami, S.-h. Urashima, M. Tsukamoto, A. Motoda, Y. Hayakawa, and H. Saigusa,
  J. Phys. Chem. Lett., 3, 571–575 (2012).
   
10. Practical Synthesis of Cyclic Bis(3'–5')diadenylic Acid (c-di-AMP).
  N. Suzuki, K.-i. Oyama, and M. Tsukamoto, Chem. Lett., 40, 1113–1114 (2011).
   
11. Gas-Phase Isolation of Diethyl Guanosine 5'-Monophosphate and Its Conformational
  Assignment.
  H. Asami, M. Tsukamoto, Y. Hayakawa, and H. Saigusa, Phys. Chem. Chem. Phys., 12,
  13918–13921 (2010).







◆学会発表 (2010年以降)
   
1. 酸アゾール複合体を促進剤に用いる反応の開発
  塚本眞幸
  若手研究者のための有機化学札幌セミナー
  2019年11月20日,北海道大学
   
2. A Solid-Supported Acidic Oxazolium Perchlorate as a Heterogeneous Catalyst
  for N-Glycosylation Reactions
  M. Tsukamoto, N. Basu, and K.-i. Oyama
  The 44th International Symposium on Nucleic Acids Chemistry, P010, November 15, 2017, Tokyo
   
3. Synthesis of Ribonucleoside 3',5'-Cyclic Monophosphorodithioates
  M. Tsukamoto, A. Fukuhara, H. Morita, and K.-i. Oyama
  The 42nd International Symposium on Nucleic Acids Chemistry, P-007, September 23, 2015, Himeji
   
4. アデノシン3',5'-環状モノホスホロジチオエートの合成
  福原充也,森田裕紀,尾山公一,塚本眞幸
  第45回中部化学関係学協会支部連合秋季大会,2P55,2014年11月30日,中部大学
   
5. 過塩素酸オキサゾリウム誘導体を触媒に用いるN-グリコシル化反応による
  ピリミジンヌクレオシドの合成
  森田裕紀,白水宏,塚本眞幸 
  日本化学会第94春季年会,1PB-075,2014年3月27日,名古屋大学
   
6. 環状ビス(3'-5')ジアデニル酸誘導体による緑藻の代謝活性の促進
  手塚修文,森田裕紀,白水宏,石田啓悟,鈴木紀尊,塚本眞幸
  日本化学会第94春季年会,1PB-076,2014年3月27日,名古屋大学
   
7. 2'-位を修飾した環状ジアデニル酸の合成およびそれらの生物活性
  手塚修文,鈴木紀尊,石田啓悟,尾山公一,青木摂之,塚本眞幸
  日本化学会第93春季年会,1PC-099,2013年3月22日,立命館大学びわこ・くさつキャンパス
   
8. Synthesis of Cyclic Bis(3'–5')diadenylic Acid (c-di-AMP) and Its 2'-Modified Analogs
  N. Suzuki, K.-i. Oyama, and M. Tsukamoto
  Asian Core Program 2012, PA20, December 12, 2012, Nanyang Technological University
   
9. Synthesis of 2'-Modified Cyclic Bis(3'–5')diadenylic Acids (c-di-AMPs)
  H. Shirouzu, N. Suzuki, K.-i. Oyama, and M. Tsukamoto
  The 39th International Symposium on Nucleic Acids Chemistry, P070, November 16, 2012, Nagoya University
   
10. 環状ジアデニル酸の効率的合成法の開発
  鈴木紀尊,尾山公一,塚本眞幸
  日本化学会第92春季年会,1PC-069,2012年3月25日,慶應義塾大学日吉キャンパス・矢上キャンパス
   
11. Non-destructive vaporization of GMP facilitated by the phosphoesterification:
  Conformational preference in the gas phase
  H. Asami, A. Motoda, M. Tsukamoto, Y. Hayakawa, and H. Saigusa
  The 37th International Symposium on Nucleic Acids Chemistry, P-022, November 11, 2010, Yokohama

◆特許出願 (2010年以降)
   
1. ピリミジンヌクレオシド誘導体の新規製造方法
  特願2013-228375.
   
2. 核酸固相合成用リンカー及び担体
  特開2013-177371、特願2013-13921
  (優先権主張番号 特願2012-16895).



◆総説 (2010年以降)
 
1.     Various Coupling Agents in the Phosphoramidite Method for Oligonucleotide Synthesis.
        M. Tsukamoto and Y. Hayakawa, In Synthesis of Therapeutic Oligonucleotides, M. Sekine and
        S. Obika, Eds., Springer, 17–39 (2018) ISBN-13: 978-9811319112.
 
2.     Recent Application of Acidic 1,3-Azolium Salts as Ppromoters in the Solution-Phase
        Synthesis of  Nucleosides  and Nucleotides.
        M. Tsukamoto and K.-i. Oyama, Tetrahedron Lett., 59, 2477­–2484 (2018).
 
3.     Ferrocene, 1,1'-bis[(2R,4R)-2,4-diethyl-1-phosphetanyl]-, stereoisomer; Ferrocene,
        1,1'-bis[(2S,4S)-2, 
4-diethyl-1-phosphetanyl]-, stereoisomer.
        M. Tsukamoto and M. Kitamura, In electronic-Encyclopedia of Reagents for Organic Synthesis,
        John Wiley & Sons, DOI: 10.1002/047084289X.rn01622 (2013).
 
4.     Reduction – Hydrogenation: C=C; Chemoselective.
        M. Tsukamoto and M. Kitamura, In Comprehensive Chirality, E. M. Carreira and H. Yamamoto,
        Eds., Elsevier, Amsterdam, Vol. 5, 246–269 (2012).

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